Early mortality from malignant mesothelioma in Italy as a proxy of environmental exposure to asbestos in children

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Abstract

Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from
MM in ≤50 years old people, considering the long latency, is likely related to asbestos
exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50
years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates
(SRs) were computed by age-class. The North-South trend of regional SRs, increasing in
>50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality
Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old
population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all
MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern
Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities
where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoroedenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.

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Authors

Lucia Fazzo - Istituto Superiore di Sanità, Roma, Italia https://orcid.org/0000-0002-6465-1780

Giada Minelli - Istituto Superiore di Sanità, Roma, Italia

Caterina Bruno - Istituto Superiore di Sanità, Roma, Italia

Pietro Comba - Istituto Superiore di Sanità, Roma, Italia

Susanna Conti - Istituto Superiore di Sanità, Roma, Italia

Marco De Santis - Istituto Superiore di Sanità, Roma, Italia

Amerigo Zona - Istituto Superiore di Sanità, Roma, Italia

Alessandra Binazzi - Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, Roma, Italia

Corrado Magnani - Università del Piemonte Orientale, Novara, Italia

Alessandro Marinaccio - Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, Roma, Italia

Ivano Iavarone - Istituto Superiore di Sanità, Roma, Italia

How to Cite
Fazzo, L., Minelli, G., Bruno, C., Comba, P., Conti, S., De Santis, M., Zona, A., Binazzi, A., Magnani, C., Marinaccio, A., & Iavarone, I. (2020). Early mortality from malignant mesothelioma in Italy as a proxy of environmental exposure to asbestos in children. Annali dell’Istituto Superiore Di Sanità, 56(4), 478-486. Retrieved from https://annali.iss.it/index.php/anna/article/view/1163
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