Human papilloma virus (HPV) genotypes prevalence in a Region of South Italy (Apulia).

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Abstract

Introduction. Since human papillomavirus (HPV) is the central casual factor in cervical cancer, understanding the epidemiology and geographical area distribution of the most prevalent HPV genotypes constitutes an important step towards development of strate-gies of prevention.
Aim. The aim of this study was to investigate the prevalence of HPV infection and to determine HPV types distribution among 822 HPV positive women and some sexual male partners in Apulia (Italy).
Methods. HPV DNA detection and genotyping was performed by nested-PCR for the L1 region and reverse line blot hybridization allowing the specific detection of 24 HPV genotyping both high risk (HR) and low risk (LR).
Results. The most prevalent HPV genotypes were HPV 16 (35%), HPV 31 (16%) HPV 6 (9%), HPV 58 and 66 (7%), followed by HPV 33 (6%), HPV 18 and 56 (4%), HPV 70 and 45 (3%), HPV 53 and 11 (2%). Currently 1.5% of tested specimens remained unclassified. Multiple infections with at last two different high- risk HPV genotypes were observed in 10% of specimens.
Conclusions.This finding adds knowledge to HPV epidemiological investigation, and addresses further studies aimed to consider public health for identifying groups at risk  for cervical cancer.

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Authors

Maria Franca Coscia - University of Bari ALDO MORO

Rosa Monno - University of Bari ALDO MORO

Andrea Ballini - University of Bari ALDO MORO http://orcid.org/0000-0001-8758-1415

Rosanna Mirgaldi - University of Bari ALDO MORO

Gianna Dipalma - University of Bari ALDO MORO

Francesco Pettini - University of Bari ALDO MORO

Vincenzo Cristallo - University of Bari ALDO MORO

Francesco Inchingolo - University of Bari ALDO MORO

Caterina Foti - University of Bari ALDO MORO

Danila de Vito - University of Bari ALDO MORO

How to Cite
Coscia, M. F., Monno, R., Ballini, A., Mirgaldi, R., Dipalma, G., Pettini, F., Cristallo, V., Inchingolo, F., Foti, C., & de Vito, D. (2015). Human papilloma virus (HPV) genotypes prevalence in a Region of South Italy (Apulia). Annali dell’Istituto Superiore Di Sanità, 51(3), 248-251. Retrieved from https://annali.iss.it/index.php/anna/article/view/118
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