First evidence of blaNDM-1 and blaOXA-23 carbapenemase genes in human body lice infesting a second-hand T-shirt in a street market in Italy

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Abstract

Background. The spread of carbapenems resistance is a public health concern. The main group of carbapenemases encoding the β-lactamases activity (bla genes) is the Metallo-β-lactamases (MBLs).

Methods. The presence of carbapenemase blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, blaOXA-58-like, and blaNDM-1 genes was screened by real time PCR in 26 Pediculus humanus insects identified from second-hand clothes in a local market in Central Italy. Bacteria diversity was also characterized through shotgun metagenomic amplification for a deep sequencing of the host-associated bacterial microbiomes.

Results. The blaOXA-23 and blaNDM-1 carbapenemases genes were found and metagenomic analysis showed a great presence of Acinetobacter species.

Conclusions. These results suggest a new potential transmission path for carbapenemase gene spread through bacteria ingested by insects infesting humans.

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Authors

Fabiola Mancini

Laura Villa

Michela Menegon

Marco Di Luca

Luciano Toma

Claudio De Liberato

Adele Magliano

Federico Romiti

Alessandra Carattoli

Alessandra Ciervo http://orcid.org/0000-0002-0664-9375

How to Cite
Mancini, F., Villa, L., Menegon, M., Di Luca, M., Toma, L., De Liberato, C., Magliano, A., Romiti, F., Carattoli, A., & Ciervo, A. (2021). First evidence of blaNDM-1 and blaOXA-23 carbapenemase genes in human body lice infesting a second-hand T-shirt in a street market in Italy. Annali dell’Istituto Superiore Di Sanità, 57(1). Retrieved from https://annali.iss.it/index.php/anna/article/view/1187
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