Ecological meta-analytic study of kidney disease in Italian contaminated sites

Kidney disease in Italian contaminated sites

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Abstract

Introduction. Environmental heavy metals exposure has been associated with kidney disease. There is also some evidence that exposure to solvents may be a risk factor for kidney disease. We estimated the risk of hospitalization for “kidney diseases” (ICD-9 580-586) and chronic kidney disease (CDK) (ICD-9 585) in residents in thirty-four Italian National Priority Contaminated Sites (NPCSs) polluted by heavy metals.

Methods. Random-effects model meta-analyses of SHR computed for each NPCS was performed for all the NPCSs together, and separately, according to the presence/absence of selected industrial activities (petrochemical/refinery and steel plants), and the presence/absence of solvents contamination.

Results. Pooled SHRs of overall NPCSs were in excess in both genders. Statistically significant excesses were found for CKD in both genders, and for “kidney diseases” in females, residing in NPCSs with the combined presence of heavy metals and solvents contamination. The pooled SHRs for CKD and “kidney diseases” were not statistically significant in excess in NPCSs with petrochemical/refinery and steel plants, and only petrochemical/refinery plants.

Conclusions. The results are suggestive of a possible kidney disease risk in population living in the above-mentioned NPCSs. Epidemiological surveillance and remediation actions in these areas are recommended.

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Authors

Marta Benedetti - Istituto Superiore di Sanità

Fabrizio Minichilli - Unità di Ricerca di Epidemiologia ambientale e Registri di patologia, Istituto di Fisiologia Clinica, Consiglio Nazionale delle ricerche (CNR), Pisa, Italy

Maria Eleonora Soggiu - Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy

Valerio Manno - Servizio di Statistica, Istituto Superiore di Sanità, Rome, Italy

Lucia Fazzo - Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy

How to Cite
Benedetti, M., Minichilli, F., Soggiu, M. E. ., Manno, V., & Fazzo, L. (2021). Ecological meta-analytic study of kidney disease in Italian contaminated sites: Kidney disease in Italian contaminated sites. Annali dell’Istituto Superiore Di Sanità, 57(4), 314-323. Retrieved from https://annali.iss.it/index.php/anna/article/view/1356
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