The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study

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Abstract

Introduction. This study aimed to estimate the incidence of SARS-CoV-2 infection among pregnant women during the first pandemic wave in Italy, and to describe COVID-19 disease characteristics and maternal and perinatal outcomes.
Materials and methods. National population-based prospective cohort study collecting information on women with SARS-CoV-2 diagnosis, confirmed within 7 days from hospital admission.
Results. The national SARS-CoV-2 rate was 6.04 per 1,000 births (95% CI 5.62-6.49) among pregnant women and 7.54 (95% CI 7.47-7.61) among women in reproductive age. 72.1% of the cohort developed mild COVID-19 disease without pneumonia nor need for ventilatory support. Severe disease was significantly associated with women’s previous
comorbidities (OR 2.55; 95% CI 0.98-6.90), obesity (OR 4.76; 95% CI 1.79-12.66) and citizenship from High Migration Pressure Countries (OR 3.43; 95% CI 1.27-9.25).

Conclusions. During the first pandemic wave in Italy, the SARS-CoV-2 rate among pregnant women was lower compared to that detected among women of reproductive age, and risks of severe COVID-19 disease and adverse maternal and perinatal outcomes were rare.

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Authors

Serena Donati - National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Edoardo Corsi - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy

Alice Maraschini

Michele Antonio Salvatore - National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Federica Baltaro - Department of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy

Rosaria Boldrini - Directorate-general of digitalization, of health informative system and of statistics, Italian Ministry of Health, 00144 Rome, Italy

Silvia Bonassisa - Department of Obstetrics and Gynecology, University Hospital Maggiore della Carità, Novara 28100, Italy

Roberto Brunelli - Department of Maternal and Child Health and Urological Sciences, Sapienza University – Policlinico Umberto I, 00161 Rome, Italy

Angelo Cagnacci - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Paediatric Sciences, IRCCS-San Martino Hospital, 16132 Genova

Paola Casucci - Sistema Informativo e Mobilità Sanitaria, Umbria Region, 06121 Perugia, Italy

Ilaria Cataneo - Department of Obstetrics and Gynecology, Ospedale Maggiore, Bologna 40133, Italy

Irene Cetin - Unit of Obstetrics and Gynecology, Hospital V. Buzzi, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences, University of Milan, Milan 20154, Italy

Elena De Ambrosi - Unit of Obstetrics and Gynecology, Ospedale Infermi, Rimini 47923, Italy

Martina Del Manso - Department of Infectious Diseases, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Massimo Fabiani - Department of Infectious Diseases, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Stefania Fieni - Department of Obstetrics and Gynecology, University Hospital of Parma, Parma 43126, Italy

Massimo Piergiuseppe Franchi - Department of Obstetrics and Gynecology, University Hospital of Verona, 37126 Verona, Italy

Enrico Iurlaro - Unit of Obstetrics, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan 55031, Italy

Livio Leo - Hospital Beauregard Valle D’Aosta, 11100 Aosta, Italy

Marco Liberati - Department of Medicine and Aging Sciences, D’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy

Lucia Li Sacchi - Osservatorio Epidemiologico Assessorato Salute Regione Siciliana, Sicily Region, 90145 Palermo, Italy

Stefania Livio - Unit of Obstetrics and Gynecology, Hospital V. Buzzi, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences, University of Milan, Milan 20154, Italy

Mariavittoria Locci - Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, 80138 Naples, Italy

Luca Marozio - Department of Obstetrics and Gynecology, University of Turin, 10124 Turin, Italy

Claudio Martini - Territorio e Integrazione Ospedale Territorio, Marche Region, 60122 Ancona, Italy

Gianpaolo Maso - Obstetrics and Gynecology, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy

Federico Mecacci - Department of Biomedical, Division of Obstetrics and Gynecology, Experimental and Clinical Sciences, University of Florence, 50134 Florence, Italy

Alessandra Meloni - Maternal and Neonatal Department, Azienda Ospedaliero Universitaria, 09042 Cagliari, Italy

Anna Domenica Mignuoli - Dipartimento Regionale Tutela della Salute, Calabria Region, 88100 Reggio Calabria, Italy

Sascia Moresi - Department of Woman and Child Health and Public Health, Section of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Luisa Patanè - Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII Hospital, Bergamo 24127, Italy

Francesca Perotti - Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia 27100, Italy

Enrica Perrone - Servizio Assistenza Territoriale, Direzione Generale Cura Della Persona, Salute e Welfare, Emilia-Romagna Region, 40127 Bologna, Italy

Federico Prefumo - Division of Obstetrics and Gynecology, ASST Spedali Civili, Department of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy

Luca Ramenghi - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

Raffaella Rusciani - Department of Epidemiology, ASL TO3 Piedmont Region, Turin 10095, Italy

Valeria Savasi - Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, 20157 Milan, Italy

Sergio Crescenzo Antonio Schettini - Center for Reproductive Medicine of San Carlo Hospital, 85100 Potenza, Italy

Daniela Simeone - Ospedale Civile Antonio Cardarelli, 86100 Campobasso, Italy

Marco Soligo - Unit of Obstetrics and Gynecology, Ospedale Maggiore di Lodi – Distretti e Presidi Lodigiani, 26900 Lodi, Italy

Martin Steinkasserer - Central Teaching Hospital of Bozen, Division of Gynecology and Obstetrics, 39100 Bozen, Italy

Saverio Tateo - Santa Chiara Hospital, 38122 Trento, Italy

Giliana Ternelli - Unit of Obstetrics and Gynecology, Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Modena 41124, Italy

Roberta Tironi - Ospedale Manzoni, Lecco 23900, Italy

Vito Trojano - Mater Dei Hospital, 70125 Bari, Italy

Patrizia Vergani - Department of Obstetrics and Gynecology, MBBM Foundation/San Gerardo Hospital, University of Milan–Bicocca, Monza 20900, Italy

How to Cite
Donati, S., Corsi, E., Maraschini, A. ., Salvatore, M. A., Baltaro, F. ., Boldrini, R. ., Bonassisa, S. ., Brunelli, R. ., Cagnacci, A., Casucci, P., Cataneo, I., Cetin, I., De Ambrosi, E., Del Manso, M. ., Fabiani, M., Fieni, S., Franchi, M. P. ., Iurlaro, E., Leo, L., Liberati, M., Li Sacchi, L., Livio, S., Locci, M., Marozio, L., Martini, C., Maso, G., Mecacci, F., Meloni, A., Mignuoli, A. D., Moresi, S., Patanè, L., Perotti, F., Perrone, E., Prefumo, F., Ramenghi, L., Rusciani, R., Savasi, V., Schettini, S. C. A. ., Simeone, D., Soligo, M., Steinkasserer, M. ., Tateo, S., Ternelli, G., Tironi, R., Trojano, V., & Vergani, P. (2021). The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study. Annali dell’Istituto Superiore Di Sanità, 57(4), 272-285. Retrieved from https://annali.iss.it/index.php/anna/article/view/1411
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