The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study

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Abstract

Introduction. This study aimed to estimate the incidence of SARS-CoV-2 infection among pregnant women during the first pandemic wave in Italy, and to describe COVID-19 disease characteristics and maternal and perinatal outcomes.
Materials and methods. National population-based prospective cohort study collecting information on women with SARS-CoV-2 diagnosis, confirmed within 7 days from hospital admission.
Results. The national SARS-CoV-2 rate was 6.04 per 1,000 births (95% CI 5.62-6.49) among pregnant women and 7.54 (95% CI 7.47-7.61) among women in reproductive age. 72.1% of the cohort developed mild COVID-19 disease without pneumonia nor need for ventilatory support. Severe disease was significantly associated with women’s previous
comorbidities (OR 2.55; 95% CI 0.98-6.90), obesity (OR 4.76; 95% CI 1.79-12.66) and citizenship from High Migration Pressure Countries (OR 3.43; 95% CI 1.27-9.25).

Conclusions. During the first pandemic wave in Italy, the SARS-CoV-2 rate among pregnant women was lower compared to that detected among women of reproductive age, and risks of severe COVID-19 disease and adverse maternal and perinatal outcomes were rare.

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Authors

Serena Donati - National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Edoardo Corsi - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy

Alice Maraschini

Michele Antonio Salvatore - National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Federica Baltaro - Department of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy

Rosaria Boldrini - Directorate-general of digitalization, of health informative system and of statistics, Italian Ministry of Health, 00144 Rome, Italy

Silvia Bonassisa - Department of Obstetrics and Gynecology, University Hospital Maggiore della Carità, Novara 28100, Italy

Roberto Brunelli - Department of Maternal and Child Health and Urological Sciences, Sapienza University – Policlinico Umberto I, 00161 Rome, Italy

Angelo Cagnacci - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Paediatric Sciences, IRCCS-San Martino Hospital, 16132 Genova

Paola Casucci - Sistema Informativo e Mobilità Sanitaria, Umbria Region, 06121 Perugia, Italy

Ilaria Cataneo - Department of Obstetrics and Gynecology, Ospedale Maggiore, Bologna 40133, Italy

Irene Cetin - Unit of Obstetrics and Gynecology, Hospital V. Buzzi, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences, University of Milan, Milan 20154, Italy

Elena De Ambrosi - Unit of Obstetrics and Gynecology, Ospedale Infermi, Rimini 47923, Italy

Martina Del Manso - Department of Infectious Diseases, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Massimo Fabiani - Department of Infectious Diseases, Istituto Superiore di Sanità - Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

Stefania Fieni - Department of Obstetrics and Gynecology, University Hospital of Parma, Parma 43126, Italy

Massimo Piergiuseppe Franchi - Department of Obstetrics and Gynecology, University Hospital of Verona, 37126 Verona, Italy

Enrico Iurlaro - Unit of Obstetrics, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan 55031, Italy

Livio Leo - Hospital Beauregard Valle D’Aosta, 11100 Aosta, Italy

Marco Liberati - Department of Medicine and Aging Sciences, D’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy

Lucia Li Sacchi - Osservatorio Epidemiologico Assessorato Salute Regione Siciliana, Sicily Region, 90145 Palermo, Italy

Stefania Livio - Unit of Obstetrics and Gynecology, Hospital V. Buzzi, ASST Fatebenefratelli Sacco, Department of Biomedical and Clinical Sciences, University of Milan, Milan 20154, Italy

Mariavittoria Locci - Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, 80138 Naples, Italy

Luca Marozio - Department of Obstetrics and Gynecology, University of Turin, 10124 Turin, Italy

Claudio Martini - Territorio e Integrazione Ospedale Territorio, Marche Region, 60122 Ancona, Italy

Gianpaolo Maso - Obstetrics and Gynecology, Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy

Federico Mecacci - Department of Biomedical, Division of Obstetrics and Gynecology, Experimental and Clinical Sciences, University of Florence, 50134 Florence, Italy

Alessandra Meloni - Maternal and Neonatal Department, Azienda Ospedaliero Universitaria, 09042 Cagliari, Italy

Anna Domenica Mignuoli - Dipartimento Regionale Tutela della Salute, Calabria Region, 88100 Reggio Calabria, Italy

Sascia Moresi - Department of Woman and Child Health and Public Health, Section of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Luisa Patanè - Department of Obstetrics and Gynecology, ASST Papa Giovanni XXIII Hospital, Bergamo 24127, Italy

Francesca Perotti - Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia 27100, Italy

Enrica Perrone - Servizio Assistenza Territoriale, Direzione Generale Cura Della Persona, Salute e Welfare, Emilia-Romagna Region, 40127 Bologna, Italy

Federico Prefumo - Division of Obstetrics and Gynecology, ASST Spedali Civili, Department of Clinical and Experimental Sciences, University of Brescia, Brescia 25123, Italy

Luca Ramenghi - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy

Raffaella Rusciani - Department of Epidemiology, ASL TO3 Piedmont Region, Turin 10095, Italy

Valeria Savasi - Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, 20157 Milan, Italy

Sergio Crescenzo Antonio Schettini - Center for Reproductive Medicine of San Carlo Hospital, 85100 Potenza, Italy

Daniela Simeone - Ospedale Civile Antonio Cardarelli, 86100 Campobasso, Italy

Marco Soligo - Unit of Obstetrics and Gynecology, Ospedale Maggiore di Lodi – Distretti e Presidi Lodigiani, 26900 Lodi, Italy

Martin Steinkasserer - Central Teaching Hospital of Bozen, Division of Gynecology and Obstetrics, 39100 Bozen, Italy

Saverio Tateo - Santa Chiara Hospital, 38122 Trento, Italy

Giliana Ternelli - Unit of Obstetrics and Gynecology, Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Modena 41124, Italy

Roberta Tironi - Ospedale Manzoni, Lecco 23900, Italy

Vito Trojano - Mater Dei Hospital, 70125 Bari, Italy

Patrizia Vergani - Department of Obstetrics and Gynecology, MBBM Foundation/San Gerardo Hospital, University of Milan–Bicocca, Monza 20900, Italy

How to Cite
Donati, S., Corsi, E., Maraschini, A. ., Salvatore, M. A., Baltaro, F. ., Boldrini, R. ., … Vergani, P. (2021). The first SARS-CoV-2 wave among pregnant women in Italy: results from a prospective population-based study. Annali dell’Istituto Superiore Di Sanità, 57(4), 272–285. Retrieved from https://annali.iss.it/index.php/anna/article/view/1411
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