First detection of SARS-CoV-2 lineage A.27 in Sardinia, Italy

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Abstract

Introduction. Multiple variants of SARS-CoV-2, since the end of 2020 have emerged in many geographical areas and are currently under surveillance worldwide highlighting the continuing need for genomic monitoring to detect variants previously not yet identified.
Methods. In this study, we used whole-genome sequencing (WGS) and phylogenetic analysis to investigate A.27 lineage SARS-CoV-2 from Sardinia, Italy.
Results. The Italian A.27 lineage genomes from Sardinia appeared related in a clade with genomes from France. Among the key mutations identified in the spike protein, the N501Y and the L452R deserve attention as considered likely vaccine escape mutations. Additional mutations were also here reported.
Conclusion. A combination of features could explain our data such as SARS-CoV-2 genetic variability, viral dynamics, the human genetic diversity of Sardinian populations, the island context probably subjected to different selective pressures. Molecular and genomic investigation is essential to promptly identify variants with specific mutations with potential impact on public health and vaccine formulation.

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Authors

Alessandra Lo Presti - Department of Infectious Diseases, Istituto Superiore di Sanità

Ferdinando Coghe - Laboratory Clinical Chemical Analysis and Microbiology, University Hospital of Cagliari, 09124 Cagliari, Italy.

Angela Di Martino - Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.

Sara Fais - Department of Surgical Sciences, Molecular Biology Service (MBS), University of Cagliari, 09124 Cagliari, Italy

Riccardo Cappai

Manuela Marra - Core Facilities - Istituto Superiore di Sanità, 00161 Rome, Italy.

Maria Carollo - Core Facilities - Istituto Superiore di Sanità, 00161 Rome, Italy.

Marco Crescenzi

Germano Orrù - Department of Surgical Sciences, Molecular Biology Service (MBS), University of Cagliari, 09124 Cagliari, Italy

Giovanni Rezza - Health Prevention Directorate, Ministry of Health, Rome, Italy

Paola Stefanelli - Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.

How to Cite
Lo Presti, A., Coghe, F., Di Martino, A., Fais, S., Cappai, R., Marra, M., … Stefanelli, P. (2022). First detection of SARS-CoV-2 lineage A.27 in Sardinia, Italy. Annali dell’Istituto Superiore Di Sanità, 58(1), 1–5. Retrieved from https://annali.iss.it/index.php/anna/article/view/1417
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