Malignant mesothelioma (MM) is rare and difficult to diagnose. Its identification depends
upon pathological investigation (cyto-histological assessment and immunohistochemistry)
supported by clinical and radiological evidence. In the last decade, the
standardization of diagnostic methods has become a major focus of debate among pathologists
and clinicians. This has led to the writing of guidelines and recommendation
for the diagnosis to achieve the goal of a standard diagnosis. In this article, a chronological
view relating to the pathological diagnosis of MM is presented together with a review
of guidelines and recommendations.