Guillain-Barré syndrome in patients dying with COVID-19 in Italy: a retrospective study

Guillain-Barré syndrome in 4 COVID-19 deads

Authors

Abstract

Introduction. We presented a four-case series of COVID-19 related deaths occurred in patients with Guillain-Barré syndrome (GBS) between February 2020 and January 2022 in Italy.
Methods. They were extracted from 8,436 medical charts of COVID-19 patients dying. All cases, ranged 48-73 years, showed classical GBS clinical onset – limb weakness, sensory deficits, hypoareflexia – and three of them were admitted in intensive care unit (ICU) for ventilator support.
Results. The cerebrospinal fluid showing albumin-cytological dissociation was performed in two cases. Nerve conduction studies supported the diagnosis in all cases. Interstitial pneumonia was documented by chest X-rays or CT scans in all cases: they were treated with intravenous immunoglobulin (IVIg) and the drugs used for COVID-19 infection.
Conclusions. Although the mechanism of GBS onset is still unclear in COVID-19, fatal cases may be more frequent than other virus-related GBS, so that strictly monitoring in high-risk patients could dramatically decrease the mortality of GBS.

Share on

Downloads

Authors

Elisa Colaizzo - istituto superiore di sanita

Maria Puopolo - Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy https://orcid.org/0000-0001-5410-2334

Dorina Tiple - Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy https://orcid.org/0000-0001-7155-4957

Luana Vaianella - Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy https://orcid.org/0000-0002-6642-8304

Nicola Vanacore - National Center for Disease Prevention and Health Promotion, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161 Rome, Italy https://orcid.org/0000-0003-2817-3758

Alberto Milanese - Department of Public Health and infectious Disease, Sapienza University of Rome, Piazzale Aldo Moro, 5 - 00185 Rome, Italy https://orcid.org/0000-0002-7168-0811

Luigi Palmieri - Department of cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy https://orcid.org/0000-0002-4298-2642

Cinzia Lo Noce - Department of cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy https://orcid.org/0000-0002-8132-2567

Marco Canevelli - Department of Human Neuroscience, Sapienza University of Rome, Piazzale Aldo Moro, 5 - 00185 Rome, Italy https://orcid.org/0000-0001-7333-6478

Alessia Perna - Institute of Neurology, Catholic University of the Sacred Heart, Largo Francesco Vito, 1 - 00168 Rome, Italy https://orcid.org/0000-0003-2268-3079

Graziano Onder - Department of cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena, 229 - 00161 Rome, Italy

and the Italian National Institute of Health COVID-19 Mortality Group

How to Cite
Colaizzo, E., Puopolo, M., Tiple, D., Vaianella, L., Vanacore, N., Milanese, A., … and the Italian National Institute of Health COVID-19 Mortality Group. (2023). Guillain-Barré syndrome in patients dying with COVID-19 in Italy: a retrospective study: Guillain-Barré syndrome in 4 COVID-19 deads. Annali dell’Istituto Superiore Di Sanità, 59(3), 194–198. https://doi.org/10.4415/ANN_23_03_04
  • Abstract viewed - 123 times