Objective. This study investigates the possible influence of global climate change (GCC) on exposure to plant protection products (PPP) in the workplace. Methods. The paper has evaluated the main potential relationships between GCC and occupational exposure to pesticides, by highlighting how global warming might affect their future use and by reviewing its possible consequence on workers’ exposure. Results. Global warming, influencing the spatial and temporal distribution and proliferation of weeds, the impact of already present insect pests and pathogens and the introduction of new infesting species, could cause a changed use of pesticides in terms of higher amounts, doses and types of products applied, so influencing the human exposure to them during agricultural activities. GCC, in particular heat waves, may also potentially have impact on workers’ susceptibility to pesticides absorption. Conclusions. Prevention policies of health in the workplace must be ready to address new risks from occupational exposure to pesticide, presumably different from current risks, since an increased use may be expected.