Purpose:This study aimed to evaluate the psychometric characteristics of the Multidimensional Scale of Perceived Social Support (MSPSS) in patients with chronic diseases. Methods:Patients (n = 236) with chronic diseases completed the MSPSS and the36-item Short Form Health Survey (SF-36). MSPSS factorial structure was analysed using Confirmatory Factor Analysis (CFA), and internal consistency reliability was evaluated with Cronbach’s alpha, the factor score determinacy coefficient, and the model-based internal consistency index. Concurrent validity was performed correlating the MSPSS scores with the SF-36 scores. Results:CFA supported the three-factor structure of the MSPSS (CFI = 0.97; RMSEA= 0.058). Cronbach’s alpha, the factor score determinacy coefficient, and the model-based internal consistency index were ³0.89. Concurrent validity was supportive with significant correlations between the MSPSS and SF-36 scores. Conclusions:The MSPSS has supportive validity and reliability and can be used to evaluate perceived social support that is received by chronic patients.