Incidence of frailty: a systematic review of scientific literature from a public health perspective



Introduction. Because of the dynamic nature of frailty, prospective epidemiological data are essential to calibrate an adequate public health response. Methods. A systematic review of literature on frailty incidence was conducted within the European Joint Action ADVANTAGE. Results. Of the 6 studies included, only 3 were specifically aimed at estimating frailty incidence, and only 2 provided disaggregated results by at least gender. The mean followup length (1-22.2 years; median 5.1), sample size (74-6306 individuals), and age of participants (≥ 30-65) varied greatly across studies. The adoption of incidence proportions rather than rates further limited comparability of results. After removing one outlier, incidence ranged from 5% (follow-up 22.2 years; age ≥ 30) to 13% (follow-up 1 year, age ≥ 55). Conclusions. Well-designed prospective studies of frailty are necessary. To facilitate comparison across studies and over time, incidence should be estimated in person-time rate. Analyses of factors associated with the development of frailty are needed to identify high-risk groups.

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Lucia Galluzzo

Rónán O’Caoimh

Ángel Rodríguez-Laso

Nathalie Beltzer

Anette Hylen Ranhoff

Johan Van der Heyden

Maria Lamprini-Koula

Marius Ciutan

Luz López-Samaniego

Aaron Liew

on behalf of Work Package 5 of the Joint Action ADVANTAGE

How to Cite
Galluzzo, L., O’Caoimh, R., Rodríguez-Laso, Ángel, Beltzer, N., Hylen Ranhoff, A., Van der Heyden, J., … 5 of the Joint Action ADVANTAGE, on behalf of W. P. (2018). Incidence of frailty: a systematic review of scientific literature from a public health perspective. Annali dell’Istituto Superiore Di Sanità, 54(3), 239–245. Retrieved from
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