A combination of infrared spectroscopy and morphological analysis allows successfully identifying rare crystals and atypical urinary stones

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Abstract

Background:

The combination of infrared spectroscopy and morphological analysis significantly improves the urinary stone analysis.

In addition to common urinary stones, it is not unusual to encounter spurious or factitious stones that, if not appropriately identified, can lead to errors in the diagnosis. In this study we shows the importance of Infrared spectroscopy and the morphological analysis, for determining the presence of drugs crystals or atypical components in the calculi.

Methods: among 1.041 urinary stones analyzed by morphocostitutional analysis the rare stones were also analyzed by chemical spot test analysis.

Results: Among 1.041 calculi analyzed, 1.018 had a known composition, 23 samples were stones with rare composition or fake urinary stones.

Conclusions: FT-IR, allows to identify, theoretically, any substance, including drug-containing calculi or calculi with unusual composition and identify false stones. This is mandatory to treat patients affected by urolithiasis with a personalized clinical approach.

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Authors

Aniello Primiano - Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia; Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italia

Silvia Persichilli - Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia; 2 Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italia

Pietro Manuel Ferraro - Istituto di Medicina Interna e Geriatria, Università Cattolica del Sacro Cuore, Roma, Italia

Angelo Minucci - Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia; Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italia

Giovanni Gambaro

Andrea Urbani - Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia; Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Roma, Italia

Jacopo Gervasoni - Fondazione Policlinico Universitario A. Gemelli IRCCS. Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore

How to Cite
Primiano, A., Persichilli, S., Ferraro, P. M., Minucci, A., Gambaro, G., Urbani, A., & Gervasoni, J. (2019). A combination of infrared spectroscopy and morphological analysis allows successfully identifying rare crystals and atypical urinary stones. Annali dell’Istituto Superiore Di Sanità, 55(3), 205-208. Retrieved from https://annali.iss.it/index.php/anna/article/view/823
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