Rehabilitation strategies for low anterior resection syndrome. A systematic review



Objective. To summarize the evidence in the literature about rehabilitative treatments that reduce low anterior resection syndrome (LARS) symptoms in patients who underwent surgery for colorectal cancer.
Methods. We have search in PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health and Scopus databases. Studies selected were limited to those including only patient undergone low rectal resection with sphincter preservation and with pre-post assessment with a LARS score. Five articles fit the criteria.
Results. The percutaneous tibial nerve stimulation demonstrated moderate results and sacral nerve stimulation was found to be the best treatment with greater symptom improvement. Only one study considered sexual and urinary problems in the outcomes assessment.
Conclusions. In clinical practice patients should evaluate with the LARS and other score for evaluation of urinary and sexual problems. Future research must be implemented with higher quality studies to identify the least invasive and most effective treatment/s.


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Giampiera Bulfone - University of Tor Vergata Rome, Italy. Department of Biomedicine and Prevention

Francesca Del Negro

Elena Del Medico

Lucia Cadorin

Valentina Bressan

Simone Stevanin

How to Cite
Bulfone, G., Del Negro, F., Del Medico, E., Cadorin, L., Bressan, V., & Stevanin, S. (2020). Rehabilitation strategies for low anterior resection syndrome. A systematic review. Annali dell’Istituto Superiore Di Sanità, 56(1), 38–47. Retrieved from
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