Microbiological ascertainment in patients with pneumonia: the experience of a teaching hospital in Rome

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Abstract

Objectives. Pneumonia still remains a problem from the clinical and public health viewpoint
because of the relevant epidemiological burden. The etiological diagnosis is important
in the light of avoiding unnecessary antibiotic treatment and choosing the most
appropriate therapeutical approach. This study is aimed at providing evidence on the
proportion of microbiological ascertainment in pneumonia-related hospitalizations in
one of the most important teaching hospitals in Rome.
Methods. The study relied on the record linkage of two administrative databases of the
same hospital: the electronic hospital discharge register and the microbiology laboratory
surveillance database.
Results. 2819 records were identified, where 46% had a microbiological ascertainment,
significantly higher in males than in females (51% vs 40%) and in cases of pneumonia
reported in secondary diagnosis instead of primary diagnosis (52% vs 42%). Medical patients
had significantly lower proportion of ascertainment compared to surgical patients
(43% vs 67%) whereas there were not differences between patients with emergency and
elective admission. The overall mortality was 17%. Mortality was significantly higher: in
surgical compared to medical patients (27% vs 15%), in ventilated compared to not ventilated
patients (41% vs 11%), in cases with secondary diagnosis of pneumonia compared
to a primary diagnosis (23% vs 11% ) and in hospitalized in intensive care unit-ICUrather
than in non-ICU (71% vs 12%).
Conclusion. The proportion of microbiological ascertaiment in pneumonia remains less
than 50%. Albeit in line with other evidence, this result should call the attention on the
impact of unknown etiological diagnosis on antibiotic treatment and resistance.

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Authors

Marianxhela Dajko - Center of Epidemiology and Biostatistics, Università Politecnica delle Marche, Ancona, Italy

Andrea Poscia - ASUR Marche – AV2 – UOC ISP Prevenzione e Sorveglianza Malattie Infettive e Cronico Degenerative, Jesi (Ancona), Italy

Brunella Posteraro - Sezione di Igiene, Istituto di Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy

Domenico Speziale - Institute of Microbiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

Massimo Volpe - Health Management, Fondazione Policlinico Universitario Agostino Gemelli , Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

Silvia Mancinelli - Department of Experimental Medicine, Università di Perugia, Italy

Walter Ricciardi - Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

Chiara de Waure - Department of Experimental Medicine, Università di Perugia, Italy

How to Cite
Dajko, M., Poscia, A., Posteraro, B., Speziale, D., Volpe, M., Mancinelli, S., Ricciardi, W., & de Waure, C. (2020). Microbiological ascertainment in patients with pneumonia: the experience of a teaching hospital in Rome. Annali dell’Istituto Superiore Di Sanità, 56(3), 277-284. Retrieved from https://annali.iss.it/index.php/anna/article/view/967
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