Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure

Authors

Abstract

Objective. Italy has been a large user of asbestos and asbestos containing materials
until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed
workers.
Methods. Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding,
glasswork, harbors, insulation and other industries). SMRs were computed by industrial
sector for the 1970-2010 period, for the major causes, using reference rates by age,
sex, region and calendar period.
Results. The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died
(cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at
the plant and period levels. Asbestos related mortality was significantly increased. All
industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.

Discussion. The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.

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Authors

Corrado Magnani - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Stefano Silvestri - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Alessia Angelini - Occupational & Environmental Epidemiology Unit - Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

Alessandra Ranucci - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Danila Azzolina - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Tiziana Cena - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Elisabetta Chellini - Occupational & Environmental Epidemiology Unit - Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

Enzo Merler - Mesothelioma Register of the Veneto Region, Regional Epidemiologic System, Local Health Unit 6, Padua, Italy.

Venere Pavone - Department of Public Health, Prevention and Security Area Work Environments, Local Health Authority, Bologna, Italy.

Lucia Miligi - Occupational & Environmental Epidemiology Unit - Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

Giuseppe Gorini - Occupational & Environmental Epidemiology Unit - Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

Vittoria Bressan - Mesothelioma Register of the Veneto Region, Regional Epidemiologic System, Local Health Unit 6, Padua, Italy.

Paolo Girardi - Mesothelioma Register of the Veneto Region, Regional Epidemiologic System, Local Health Unit 6, Padua, Italy.

Lisa Bauleo - Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.

Elisa Romeo - Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.

Ferdinando Luberto - Epidemiology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy

Orietta Sala - Occupational Hygienist. Formerly: Regional Agency for Prevention, Environment and Energy Emilia-Romagna, Provincial Office of Reggio Emilia, Italy.

Corrado Scarnato - Department of Public Health, Prevention and Security Area Work Environments, Local Health Authority, Bologna, Italy.

Simona Menegozzo - National Cancer Institute IRCCS Fondazione Pascale, Naples, Italy.

Enrico Oddone - Department of Public Health, Experimental and Forensic Medicine, University of Pavia, and ICS Maugeri IRCCS, Pavia, Italy.

Sara Tunesi - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

Patrizia Perticaroli - Prevention Department, ASUR Marche, Senigallia, Italy.

Aldo Pettinari - Prevention Department, ASUR Marche, Senigallia, Italy.

Francesco Cuccaro - Unit of Epidemiology and Statistics - Local Health Unit of Barletta-Andria-Trani, Barletta, Italy.

Stefano Mattioli - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

Antonio Baldassarre - Occupational Medicine Unit, Careggi University Hospital, Florence, Italy.

Francesco Barone-Adesi - Unit of Hygiene, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara,Italy.

Marina Musti - Interdisciplinary Department of Medicine, Occupational Medicine "B. Ramazzini", University of Bari, Bari, Italy.

Dario Mirabelli - Unit of Cancer Epidemiology, CPO Piedmont and University of Turin, Turin, Italy.

Roberta Pirastu - Department of Biology and Biotechnologies "Charles Darwin", Sapienza University, Rome, Italy.

Alessandro Marinaccio - Italian Workers' Compensation Authority (INAIL), Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Unit of Occupational and Environmental Epidemiology, Italian Mesothelioma Register, Rome, Italy.

Stefania Massari - Italian Workers' Compensation Authority (INAIL), Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Unit of Occupational and Environmental Epidemiology, Italian Mesothelioma Register, Rome, Italy.

Daniela Ferrante - Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, Novara, Italy.

for the Working Group Studio Multicentrico Italiano di Coorti di lavoratori dell’Amianto (SMICA)

How to Cite
Magnani, C., Silvestri, S., Angelini, A., Ranucci, A., Azzolina, D., Cena, T., Chellini, E., Merler, E., Pavone, V., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Bauleo, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Barone-Adesi, F., Musti, M., Mirabelli, D., Pirastu, R., Marinaccio, A., Massari, S., Ferrante, D., & Multicentrico Italiano di Coorti di lavoratori dell’Amianto (SMICA), for the W. G. S. (2020). Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure. Annali dell’Istituto Superiore Di Sanità, 56(3), 292-302. Retrieved from https://annali.iss.it/index.php/anna/article/view/990
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