Combined HLA matched limbal stem cells allograft with amniotic membrane transplantation as a prophylactic surgical procedure to prevent corneal graft rejection after penetrating keratoplasty: case report

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Abstract

Purpose. To determine if the use of combined HLA matched limbal stem cells allograft  with  amniotic  membrane  transplantation  (AMT)  is  a  safe  and  effective  prophylactic  surgical procedure to prevent corneal graft after penetrating keratoplasty (PK).
Methods.  We  report  the  case  of  a  17  years  old  patient  with  a  history  of  congenital  glaucoma, trabeculectomy and multiple corneal graft rejections, presenting total limbal  cell deficiency. To reduce the possibility of graft rejection in the left eye after a new PK,  a two step procedure was performed. At first the patient underwent a combined HLA  matched limbal stem cells allograft (LAT) and AMT and then, 10 months later, a new  PK.
Results. During 12 months of follow-up, the corneal graft remained stable and smooth,  with no sign of graft rejection.
Conclusions. In our patient, the prophylactic use of LAT from HLA-matched donors  and AMT before PK, may result in a better prognosis of corneal graft survival.
 
 
 

 

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Authors

Paolo Capozzi

Sergio Petroni

Luca Buzzonetti

How to Cite
Capozzi, P., Petroni, S., & Buzzonetti, L. (2014). Combined HLA matched limbal stem cells allograft with amniotic membrane transplantation as a prophylactic surgical procedure to prevent corneal graft rejection after penetrating keratoplasty: case report. Annali dell’Istituto Superiore Di Sanità, 50(3), 298–300. Retrieved from https://annali.iss.it/index.php/anna/article/view/64
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