Use of probiotics in medical devices applied to some common pathologies.



Probiotics, defined as “living microorganisms that, whether ingested in useful amount, may have beneficial effects on human body”, are widely used in various products for human use, such as dietary supplements, medical devices and pharmaceutical products. The European Directive on medical devices (MDs) (DDM 93/42), also includes those MDs containing live microorganisms, particularly probiotics, that may have various destinations of use, including that of assisting the therapy of several human pathologies. In this brief note we analyzed the use of probiotics in MDs and how probiotics administration could represent one of the new frontiers of scientific research on the prevention and treatment of various diseases. We’ll analyze the literature on probiotics based MDs, to review their major targets in the therapy of some of the most common human pathologies: bacterial vaginosis and vaginitis, atopic dermatitis, infant colic, obesity, type 2 diabetes, and pharyngotonsillitis.

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Maria Verrucci - Istituto Superiore di Sanità

Angelo Iacobino - Istituto Superiore di Sanità

Lanfranco Fattorini - Istituto Superiore di Sanità

Roberta Marcoaldi - Istituto Superiore di Sanità

Antonino Maggio - Istituto Superiore di Sanità

Giovanni Piccaro - Istituto Superiore di Sanità

How to Cite
Verrucci, M., Iacobino, A., Fattorini, L., Marcoaldi, R., Maggio, A., & Piccaro, G. (2019). Use of probiotics in medical devices applied to some common pathologies. Annali dell’Istituto Superiore Di Sanità, 55(4), 380–385. Retrieved from
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